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Document 2506
DOCN M94A2506
TI HIV-1 serotypes in Thailand during 1985-1994.
DT 9412
AU Louisirirotchanakul S; Wasi C; Surisance V; Kanoksinsombat C; Young N;
Vanichseni S; Thongcharoen P; Faculty of Medicine Siriraj Hospital,
Bangkok, Thailand.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):289 (abstract no. PC0076). Unique
Identifier : AIDSLINE ICA10/94370069
AB OBJECTIVE: To study on the HIV serotypes in Thailand during 1985-1994,
by using a high specific V3 peptide based enzyme immunoassay. METHODS:
From 1985-1994, a total of 307 anti HIV-1 positive sera collected from
30 homo/bisexual, 145 heterosexual and 132 intravenous drug users (IVDU)
were studied the serotypes based on the synthetic V3. The antigen,
derived from 15 amino acid of the V3 loop peptides from Thai genotype A
and Thai genotype B as previous described, were provided from CDC,
Atlanta, USA. RESULTS: The two serotypes of HIV-1 are circulating in
Thailand. The genotype Thai A or subtype E was introduced lately since
1988 and predominate in the sexual transmission group i.e. 85% while
genotype Thai B or subtype B was found in 1987 and predominate among
IVDU i.e. 73%. There were some sera which were not reacted with the two
peptides. DISCUSSION AND CONCLUSION: The epidemic of HIV-1 just started
in Thailand, during 1985-1986 only few cases of homosexual were found
positive. The outbreak in IVDU was notified in the early of 1988 and
spread to the heterosexual. The subtypes difference was found in the
sexual and injection transmission route. The subtype E which introduced
in 1988 showed the strong predominate now. This findings are important
for the effective vaccine design.
DE Human HIV Seropositivity/*MICROBIOLOGY HIV-1/*CLASSIFICATION
Serotyping Thailand MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).